Currently, I'm writing my master thesis using these words very much as conjunctions to give the meaning of 'because of that', 'for that reason' and 'in doing so'. In order to provide a better understanding of how I'm using them, I'll give some examples. As a matter of fact, almost no system is purely deterministic; therefore, some drawbacks in comparison to stochastic simulations arise, such as ... Deterministic approaches can give us a hint about one possibility that the system under the observation might undergo, and; thereby (thus), other possibilities are left out. I'm not sure if the examples show what I have in my mind as a difference between 'therefore' and 'thereby,thus', but I would like to know the exact difference among them if there is. In some of the local English grammar books, it is mentioned that they can be used interchangeably, and this causes some confusion.