"What is the product of the numbers 2 and 8?" If I wanted to use the word 'multiplication' instead of 'product', how would you construct the sentence ? Would " What is the answer of the multiplication of 2 and 8 ?" be correct ? Thanks.

If you insist on the word multiplication, the sentence is going to be very complicated. Why do you want to do that?

Yes. Would you be satisfied by: What is 2 multiplied by 8? That is the way the question is asked of children who are learning their multiplication tables, as we call them.