Handsome cannot be used for women.
Actually, it is used for women. I have seen many handsome women, and heard many described as such. It's not so much an everyday expression, but it is definitely used.
Saludos,
Usually if you call a boy or man "beautiful" as in "you are a beautiful boy" it sounds like you are talking about his character more than his looks. You are a beautiful person, you have a beautiful personality, you are wonderful! If you call a boy pretty, it implies that he looks feminine.
Yes, Jane Austen used it a lot.Originally posted by Alacant
In England handsome is used to describe women, and not just in a negative way.
from dictionary.com
1.having an attractive, well-proportioned, and imposing appearance suggestive of health and strength; good-looking: a handsome man; a handsome woman.
I think of Catherine Zeta-Jones as a handsome woman, but Sarah Michelle Gellar is pretty.