Be safe! or Drive safe!

It is commonly used here in US, when saying good byes or driving off to say to kids or friends 'be safe" and/or "drive safe"

Is it very common to say
"dirigir seguro" ???
I see that "Cuidar-se" is more natural way to say those.

Any good way to say those in very casual way?

PS: I am still struggling when to use "-se"
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