I detest liars like you, I believe that honesty is the best policy.
I detest liars, like you, I believe that honesty is the best policy.
I ran into these two sentences in a English learning web in which a chapter tells me how commas can be important and also says "misplacing a comma may lose friend(s)". Now I am thoroughly confused about the quoted ones. Could you please tell me what difference is between them? Thank you.