From the Chicago Manual of Style:
5.49 Unless it is restrictive (see 5.50) a word, phrase, or clause that is in apposition to a noun is usually set off by commas….
The leader of the opposition, Senator Darkswain, had had an unaccountable change of heart.
Jeanne DeLor dedicated the book to her only sister, Margaret.
My wife, Elizabeth, had written to our congressman.
5.50 If the appositive has a restrictive function, it is not set off by commas:
My son Michael was the first one to reply.
Walpole had borrowed the rusty bread slicer from his friend Teetering.
So you decide on commas based on whether you believe your usage falls into 5.49 or 5.50.
I like 5.50 for If he were to tell his wife Sasha, then...
But I can see where others would like 5.49 for If he were to tell his wife, Sasha, then...
That’s why I said it was my opinion.