I was just looking for a way to say "leading of the Holy Spirit" in Spanish. I think many people use "guianza" in this context, although "guía" seems to be the correct word, as nanel said.
And, as LLCoolC said, "guianza" is an equivalent for "guidance".
I too thought to use "guianza" but then my Word processor and my second thought went with "guía", like "con la guía del Espíritu Santo". But I checked Google and found this interesting thread, probably under the guidance of that Spirit.