He came from this direction.

[8769]

I understand #1 below is natural English. How about #2?

He came ( ) this direction.​

1. in​

2. from​

 

[AWordLover]

Sure, they are both perfectly good.

 

[8769]

Thanks, AWordLover, for your promp reply.

How about the following sentence then?

The sun rises ( ) the east.
1. in
2. from

 

[cycloneviv]

As AWL said, they both work, but they don't mean the same thing.

He came in this direction = He came towards where we are now;
He came from this direction = He came from here and went somewhere else.