They recognized the similarity between the concept of feedback, the interplay of thesis and antithesis in the dialectic of Hegel and Marx and, for instance, the economic theory of Adam Smith that argues for the self-regulation of markets. All of these ideas implied circular patterns of causality that can be represented by feedback loops. It was the major achievement of cybernetics and informed investigations in other fields, such as biology and psychiatry. I have a question. What is the meaning of 'informed investigations'? In particular, I can't catch the meaning of 'inform'.