No matter what

Dennis Lee

Senior Member
Hong Kong
Hi all! I have a question.
The sentence is easy to understand. But which one below is more natural? I'm not sure which one is understandable and idiomatic.:confused::confused::confused:
A. No matter what adversities you undergo and what setbacks you encounter, don’t lose heart or hope.
B. No matter what adversity and setbacks you encounter, don’t lose heart or hope.
 
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