Here is the the original sentence:
The proposed configuration would reduce the necessary labor by 25% bringing the number of employees needed to perform this work from 16 to 12 resulting in an annual cost savings of $197,984.
It's a close call. On balance, Parla's version appeals more to me than Paul's. The "resulting" clause is also parenthetical, and so is on an equal footing with the "bringing" clause. This justifies an "and", but I would be tempted on this occasion to keep the second comma even if using "and". This comma would not normally be needed in a two-item enumeration, but the length of the middle clause makes it desirable.
If you don't want to think of the "resulting" clause as parenthetical, it would have to be at a higher level than the parenthetical "bringing" clause. In that case I think we'd need the second comma and the and, and we'd also need to change resulting to result, representing "and would result".