If I understand what you're asking, I'd say that this question is used most often to inquire about non-physical characteristics.
To ask about a person's appearance, I think "What does he look like" is the most common question.
Actually, both spellings can be used for the adjective, and both can be used for the noun. The word comes from French, where the difference in spelling indicates a difference in gender rather than a difference in a part of speech. If one wants to use both spellings in English, one might speak of a blond man or a blonde woman.Blond is an adjective: she has blond hair.
Blonde is a noun: she is a blonde. The blonde over there is my sister.