"What's up with you?" can also be used as a conversation starter much like "How are you doing?", "What's happening?", "What's going on?
"What's got into you?" can also be used to mean "Why are you so excited/energetic/different today?"
What's up with you?
- Might be a simple greeting - see post #2
- Could be in response to some observed behaviour
What has got into you?
- Definitely not just a greeting.
- It's an enquiry based on something you did or said that I perceive to be unusual or exceptional in some way - either positive or negative. It expresses more surprise than "What's up with you?"
What's wrong with you?
- Again, definitely not a greeting.
- It could be equivalent to "What has got into you?" asked on the basis of something negative.
- It could also, in specific contexts, be a question about your physical or mental health.